Basic Science

Latest journal articles on bone and joint basic science research from Osteoarthritis and Cartilage, Journal of Orthopaedic Research, Journal of Biomechanics, Connective Tissue Research, Journal of Applied Biomechanics, The Bone & Joint Journal, Journal of Bone and Joint Surgery, Clinical Orthopaedics and Related Research, Acta Orthopaedica, Orthopedic Clinics of North, America, Journal of Orthopaedic Surgery and Research, Orthopedics

Related Articles Individual density-elasticity relationships improve accuracy of subject-specific finite element models of human femurs. J Biomech. 2013 Jul 26; Authors: Eberle S, Göttlinger M, Augat P Abstract In a previous study on subject-specific finite-element-models, we found that appropriate density-elasticity relationships to compute the mechanical behavior of femurs seem to be subject-specific. The purpose of this study was to test the hypothesis that the predictive error of a cohort of subject-specific finite element-models is lower with subject-specific density-elasticity relationships than with a cohort-specific density-elasticity relationship. Finite-element-analysis and inverse optimization based on response surface methodology were employed to test the hypothesis. Subject-specific FE-models of 17 human femurs and corresponding experimental data from biomechanical tests were taken from a previous study. A power function for the relation between radiological bone density and elastic modulus was set up with the optimization variables a and b: E(MPa)=aρqCT(b)(gK2HPO4/cm(3)). The goal of the optimization was to minimize the root-mean-square error in percent (RMSE%) between computational and experimental results. A Wilcoxon test (p=0.05) was performed on all absolute relative errors between the two groups (subject-specific functions vs. cohort-specific function). The subject-specific functions resulted in a 6% lower overall prediction error and a 6%

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Related Articles Effects of growth on residual stress distribution along the radial depth of cortical cylinders from bovine femurs. J Biomech. 2013 Jul 26; Authors: Yamada S, Tadano S Abstract

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Related Articles Growth factors in human serum during operative tibial lengthening with the Ilizarov method. J Orthop Res. 2013 Jul 24; Authors: Stogov MV, Luneva SN, Novikov KI Abstract

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Related Articles COMP-Ang1 promotes chondrogenic and osteogenic differentiation of multipotent mesenchymal stem cells through the Ang1/Tie2 signaling pathway. J Orthop Res. 2013 Jul 24; Authors: Kim S, Lee JC, Cho ES, Kwon J Abstract

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Related Articles Improvement in the detection rate of PJI in total hip arthroplasty through multiple sonicate fluid cultures. J Orthop Res. 2013 Jul 26; Authors: Janz V, Wassilew GI, Hasart O, Tohtz S, Perka C Abstract

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Related Articles Metal presence in hair after metal-on-metal resurfacing arthroplasty. J Orthop Res. 2013 Jul 24; Authors: Rodríguez de la Flor M, Hernández-Vaquero D, Fernández-Carreira JM Abstract

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Related Articles Histone deacetylase inhibitors as potential therapeutic approaches for chordoma: An immunohistochemical and functional analysis. J Orthop Res. 2013 Jul 24; Authors: Susanne S, Birgit L, Beate R, Verena FE, Alfred B, Franz Q, Aron L, Pal VP, Johannes H, Andreas L, Bernadette L Abstract

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Related Articles Osteoarthritis Year 2013 in Review: Imaging. Osteoarthritis Cartilage. 2013 Jul 23; Authors: Mosher TJ, Walker EA, Petscavage-Thomas J, Guermazi A Abstract PURPOSE: To review recent original research publications related to imaging of osteoarthritis and identify emerging trends and significant advances. METHODS: Relevant articles were identified through a search of the PubMed database using the query terms "osteoarthritis" in combination with "imaging", "radiography", "MRI", "ultrasound", "computed tomography",and "nuclear medicine"; either published or in press between March 2012 and March 2013. Abstracts were reviewed to exclude review articles, case reports, and studies not focused on imaging using routine clinical imaging measures. RESULTS: Initial query yielded 932 references, which were reduced to 328 citations following the initial review. MRI (118 references) and radiography (129 refs) remain the primary imaging modalities in OA studies, with fewer reports using CT (35 refs) and ultrasound (23 refs). MRI parametric mapping techniques remain an active research area (33 refs) with growth in T2*- and T1rho mapping publications compared to prior years. Although the knee is the major joint studied (210 refs) there is interest in the hip (106 refs) and hand (29 refs). Imaging continues to focus on evaluation of cartilage (173 refs) and bone (119 refs).

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Related Articles Surfactant treatments influence drying mechanics in human stratum corneum. J Biomech. 2013 Jul 25; Authors: German GK, Pashkovski E, Dufresne ER Abstract We describe a high-throughput method capable of quantifying the elastic modulus and drying stress of ex vivo samples of human stratum corneum. Spatially resolved drying deformations in circular tissue samples are measured, azimuthally averaged and fitted with a profile based on a linear elastic model. Our approach enables the comparison of the physical effects of different cleansers. We find that cleansing can cause dramatic changes to the mechanical properties of stratum corneum. In some cases, cleansing can lead to an order of magnitude increase in elastic modulus and drying stress. We expect that these mechanical properties have a direct impact on cracking and chapping skin as well as the milder sensation of perceived tightness often experienced after washing. Mechanical drying studies are also combined with drop wetting studies and pyranine staining experiments. This combination of techniques allows one to establish a multidimensional profile of stratum corneum including stiffness, susceptibility to drying, hydrophilicity and barrier functionality. PMID: 23891567 [PubMed - as supplied by publisher]Read more... http://www.ncbi.nlm.nih.gov/pubmed/23891567?dopt=Abstract

Related Articles On the accuracy of the Head Impact Telemetry (HIT) System used in football helmets. J Biomech. 2013 Jul 25; Authors: Jadischke R, Viano DC, Dau N, King AI, McCarthy J Abstract

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