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Orthopaedia

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Bone Metabolism and Osteoporosis
Frailty is a state of vulnerability associated with aging, physiological decline, and depleted reserves. Frail people have impaired homoeostasis. As such, a relatively minor stressor event (such as a...

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Basic Science
Gout and pseudogout are crystalline arthropathies, that is, diseases producing recurrent attacks of acute inflammatory arthritis due to the deposition of crystals in the joints. Gout is caused by an i...

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Basic Science
Fibromyalgia is a disorder of chronic, widespread musculoskeletal pain associated with fatigue, cognitive dysfunction, mood disorders, and sleep disturbances. Fibromyalgia is a controversial disease e...

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Basic Science
Compartment syndrome describes the state of increased pressure in a closed tissue space that impairs blood flow to that space. In turn, the lack of perfusion leads to hypoxia and damage to the muscles...

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Pediatric Orthopaedics
Lyme disease is an illness that affects multiple body systems. It is caused by the spirochete Borrelia burgdorferi, which is transmitted by the Ixodes tick. Ticks are generally located on low-lying ve...

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Pediatric Orthopaedics
Transient synovitis is self-limited inflammation of the synovium. It can occur in any large joint, however it most commonly occurs in the hip. The pathophysiology of transient synovitis is poorly unde...

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Pediatric Orthopaedics
Septic arthritis is an infection of a joint. It occurs most commonly in the large joints of the lower extremities, such as the knees and hips, however it can occur in other locations as well. Septic a...

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Pediatric Orthopaedics
Osteomyelitis represents an infection of bone. In children, it occurs most commonly in the metaphysis of long bones. About two-thirds of cases occur in the lower extremity, with the femur and tibia mo...

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Pediatric Orthopaedics
Osteogenesis imperfecta is a connective tissue disease characterized by extremely fragile bones due to an autosomal dominant genetic defect in type 1 collagen production. There are four main types of...

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