Maintenance notice: Some features that submit or update information are temporarily disabled while we migrate the website. You can continue browsing normally. Thank you for your understanding.
Osteogenesis imperfecta is a connective tissue disease characterized by extremely fragile bones due to an autosomal dominant genetic defect in type 1 collagen production. There are four main types of osteogenesis imperfecta: type I is the most common and the mildest form of the disorder, and is caused by an inadequate production of type 1 collagen. The remaining types are characterized by abnormal type 1 collagen formation. In addition to bone disorders, osteogenesis imperfecta is associated with blue sclera (Figure 1); lax ligaments; hearing impairments; facial abnormalities; short stature; scoliosis or kyphosis; and dental abnormalities.
Full Article - https://www.orthopaedia.com/osteogenesis-imperfecta/
If you have orthopedic information that you would like to share with the Orthogate Community, please register/login and submit your news, event, job, article, case or workshop from the Submit Content menu under the My Account area. Learn more!
Improving orthopaedic care, education and research using Internet technologies