Life after residency will be what you make of it based on job selection. You need to find the job that works for you. I would suggest that you read through this previous thread.
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As for vacation issues, that will definitely vary with your group. I typically take about six weeks off a year. However, taking more than two weeks in a row is a significant disruption to your practice and to your partners as they will have to see some of your patients and take more call while you're gone.