The researchers conducted a meta-analysis of 23 cross-sectional and longitudinal studies of patients who underwent revision hip and knee arthroplasty. They found that the most common markers were interleukin-17 (area under the curve [AUC] 0.974), leukocyte esterase (AUC 0.968), α-defensin (AUC 0.958), interleukin-6 (AUC 0.956), interleukin-1β (AUC 0.948), and C-reactive protein (AUC 0.927), all of which had high diagnostic utility. Among those markers, α-defensin displayed the highest diagnostic odds ratio, but the difference was not statistically significant. Learn more...
