The research team reviewed data from the Osteoarthritis Initiative on 640 overweight (BMI ≥ 25 kg/m2) and obese (BMI ≥ 30 kg/m2) participants, with risk factors for osteoarthritis (OA) or mild to moderate radiographic findings of OA. Patients were assessed via Whole-Organ Magnetic Resonance Imaging Score (WORMS) at baseline and 48 months, and categorized into three groups based on weight loss. Compared with patients in the stable weight cohort (n = 320), the research team found that the adjusted mean increase of cartilage WORMS was smaller in the 5 percent to 10 percent weight loss cohort (n = 238) and smallest in the > 10 percent weight loss cohort (n = 82). Learn more...
