Scientists have pinpointed the mechanism by which a key gene contributes to the development of a painful bone disease.
Researchers have found that a fault in the gene can trigger the bone defects that affect people with Paget's disease, a condition that leads to bone pain, bone deformity and arthritis. The disease affects up to one million people in the UK.
The team is the first to identify that the gene - called OPTN - regulates the activity of specialised cells that keep bones healthy by breaking down old bone and replacing it.
