Compared with paired controls, micro-CT analysis showed that local elution of alendronic acid increased periimplant bone at both doses of 0.2 mg (+52%, p = 0.01) and 1.0 mg (+152%, p = 0.004) with 1.0 mg resulting in a 2.9-fold greater mean relative increase compared with 0.2 mg (p = 0.002). Micro-CT measurements of periimplant bone formation correlated very strongly with the backscattered scanning electron microscopy measurements (R = 0.965, p < 0.001).
CONCLUSIONS: Local elution of alendronic acid causes a dose-dependent net increase in periimplant bone formation in an animal model.
CLINICAL RELEVANCE: This concept has potential to improve the biologic fixation of porous reconstructive implants.
LEVEL OF EVIDENCE: Level II, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
CONCLUSIONS: Local elution of alendronic acid causes a dose-dependent net increase in periimplant bone formation in an animal model.
CLINICAL RELEVANCE: This concept has potential to improve the biologic fixation of porous reconstructive implants.
LEVEL OF EVIDENCE: Level II, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
PMID: 23813239 [PubMed - as supplied by publisher]
Read more... http://www.ncbi.nlm.nih.gov/pubmed/23813239?dopt=Abstract
