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De Quervain’s Tenosynovitis: Diagnosis, Treatment

De Quervain’s Tenosynovitis: A Comprehensive Review of Diagnosis and Treatment

De Quervain’s tenosynovitis, with a prevalence of 0.5% in men and 1.3% in women 1, is a common condition characterized by pain and inflammation of the tendons on the thumb side of the wrist. Specifically, it affects the abductor pollicis longus (APL) and the extensor pollicis brevis (EPB) tendons 2. These tendons control thumb movement and are located at the radial styloid process, where they pass through a fibrous tunnel or sheath 2. De Quervain’s tenosynovitis arises when these tendons become constricted within their sheath, leading to … Read more

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Chapter 7 Inflammation

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Inflammation – A Delicate Balance

This chapter delves into the complex process of inflammation, a double-edged sword in the human body. While essential for healing and defense against foreign invaders, inflammation can also become a destructive force in chronic conditions like rheumatoid arthritis.

The chapter breaks down the intricate cellular and molecular events that drive inflammation. It explores the roles of various agents, including cytokines, chemokines, and arachidonic acid metabolites, in orchestrating the inflammatory response. It also highlights the differences between acute and chronic inflammation, emphasizing the potential for long-term damage in the latter.

Key concepts include:

  • The Inflammatory Process:
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Chapter 3 Synovial Tissue

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This chapter discusses synovial tissue, which is found in joints, tendon sheaths, and bursae and facilitates smooth motion. The synovium, a membranous structure, lines these areas and produces synovial fluid, which is crucial for motion and metabolism. The chapter covers the physiology, histology, and anatomy of normal synovium and synovial fluid, and then explores various pathologic conditions that can affect the synovium.

The physiologic function of the synovium is to secrete fluid, allowing smooth passage of tendons and decreasing friction in joints, tendon sheaths, and bursae. Synovial joints have opposing surfaces covered with articular cartilage and are enclosed by a … Read more

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