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Aggrecans – An aggregating form of proteoglycan composed of many glycosaminoglycan chains bound to a protein core

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Proteoglycans are complex macromolecules that consist of a protein core with covalently bound polysaccharide (glycosaminoglycan) chains (Fig. 3).

Figure 3 Schematic diagram of a proteoglycan. The protein core has several globular domains (G1, G2, and G3), with other regions containing the keratan sulfate and chondroitin sulfate glycosaminoglycan chains. The N-terminal G1 domain is able to bind specifically to hyaluronate.This binding is stabilized by link protein. (Reproduced from Mankin HJ, Mow VC, Buckwalter JA, Iannotti JP, Ratcliffe A: Articular cartilage structure, composition, and function, in Buckwalter JA, EinhornTA, Simon SR (eds): Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal System, ed 2. Rosemont, IL, American Academy of Orthopaedic Surgeons, 2000, pp 443-470.)

 

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