Hematopoiesis, the process of forming blood cells, normally occurs in tandem with the processes of skeletal and mineral homeostasis and not in opposition to them.

Nonetheless, diseases of hematopoiesis may impact bone health. Specifically, hematologic malignancies are often found in bone. Also, because the bone is part of the circulatory system (albeit a place where circulation moves sluggishly), metastatic tumor deposits are often found in bone as well. Likewise, circulating bacteria may lodge in the bone causing osteomyelitis.