Three types of cells, osteoblasts, osteocytes, and osteoclasts, are essential to the development of bone and its dynamic remodeling (ie, the process of bone resorption and deposition that releases and deposits ions, adapts the bone to new loads, and repairs microscopic damage).

All three types of cells can be seen in any given area of bone, and many metabolic bone diseases are caused by loss of regulation, resulting in disorders of bone formation or remodeling.