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Ishman Woodard volunteers for START in Winston-Salem, North Carolina. Daniel Hamm and Jovita Newman monitor his progress.

Three times a week, thousands of people with knee osteoarthritis lift weights, have their blood pressure checked, and walk around a track at gyms in central and western North Carolina.

Some of them also take nutrition classes and listen to lifestyle lectures. Others count their calories.

But everyone has their blood work done, has their leg strength tested, gets bone density scans, and fills out quality-of-life questionnaires.

These North Carolinians are part of clinical trials led by Stephen Messier, PhD. He is the director of the J.B.

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