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A study published in the November issue of the Journal of the AAOS seeks to identify synovial fluid markers with high diagnostic utility for diagnosis of periprosthetic joint infection (PJI). 

The researchers conducted a meta-analysis of 23 cross-sectional and longitudinal studies of patients who underwent revision hip and knee arthroplasty. They found that the most common markers were interleukin-17 (area under the curve [AUC] 0.974), leukocyte esterase (AUC 0.968), α-defensin (AUC 0.958), interleukin-6 (AUC 0.956), interleukin-1β (AUC 0.948), and C-reactive protein (AUC 0.927), all of which had high diagnostic utility. Among those markers, α-defensin displayed the highest diagnostic odds ratio, but the difference was not statistically significant. Learn more...