Print

Data from a study published online in the journal JAMA Surgery suggest that perioperative administration of gabapentin may have a modest effect on promoting opioid cessation following surgery. 

The authors conducted a randomized, double-blind, placebo-controlled trial of 410 surgery patients who received either 1200 mg of gabapentin preoperatively followed by 600 mg of gabapentin three times a day postoperatively (n = 208) or active placebo (n = 202). In an intention-to-treat analysis, they found that perioperative gabapentin did not affect time to pain cessation. However, patients in the gabapentin cohort saw a 24 percent increase in the rate of opioid cessation after surgery. The authors found no significant difference across cohorts in number of adverse events or rate of medication discontinuation due to sedation or dizziness. Learn more...