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According to a study published in the May 1 issue of the Journal of the AAOS, naproxen coupled with intra-articular (IA) corticosteroids may be an effective treatment for patients treated conservatively for knee osteoarthritis (OA). 

The authors conducted a network meta-analysis of 53 randomized, controlled trials that included a minimum of 30 patients in each study group. For pain, they found that all active treatments were more effective than oral placebo, with IA corticosteroids having the largest magnitude of effect and significant difference only over IA placebo. For function, the authors noted that no IA treatments showed significance compared with either placebo, and naproxen was the only treatment that displayed clinical significance compared with oral placebo. They write that cumulative probabilities showed naproxen to be the most effective individual treatment, and when combined with IA corticosteroids, was the most likely to improve pain and function. Learn more... or Read the abstract...