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A study published online in the journal Scientific Reports suggests a link between sex-specific microRNAs in synovial fluid and osteoarthritis (OA) progression. 

The researchers isolated exosomes in discarded human synovial fluid from patients with and without OA, and demonstrated sex-specific microRNA profiling in extracellular vesicles of synovial fluid linked to OA. The researchers suggest that differentially expressed female microRNAs might be estrogen-responsive and play a role in toll-like receptor signaling during pathogenesis of OA. Learn more...