A study conducted in China and published online in the journal Anesthesiology suggests that genetic variation of brain-derived neurotrophic factor (BDNF) may be linked with an increased risk of chronic postsurgical pain. 

Members of the research team genotyped 638 polymorphisms within 54 pain-related genes across 1,152 surgical patients enrolled in the Persistent Pain after Surgery Study. At 12-month follow-up, they found that 21.4 percent (n = 246) of patients reported chronic postsurgical pain. Overall, 42 polymorphisms were associated with chronic postsurgical pain—19 decreased the risk of pain and 23 increased the risk of pain. In both the discovery cohort and matched validation cohorts of 103 patients each, researchers found that patients carrying allele A of rs6265 polymorphism in BDNF had a lower risk of chronic postsurgical pain. Learn more...

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