Genetic changes linked with increased risk of lumbar spinal stenosis

A study published online in the Journal of Orthopaedic Research suggests that certain genetic changes may be associated with an increased risk of developing lumbar spinal stenosis. The researchers conducted a genome-wide association study of 469 patients aged 18 to 55 years. 

They found that low-density lipoprotein receptor-related protein 5 on chromosome 11 was an important functional gene in canal body development. "With better understanding of the DSS phenotype and genetic markers," the researchers write, "the at-risk population can be identified early, preventative measures can be initiated, lifestyle/activity modification can be implemented, and more novel and precision-based therapeutics can be developed." Learn more...

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