Findings from a canine study published online in CORR suggest that an application of adipose-derived mesenchymal stromal cells (ASCs) and bone morphogenetic protein-12 (rBMP-12) may help accelerate healing in the proliferative stage of tendon repair. 

The researchers applied ASC sheets, both with and without rBMP-12, to the surface of sutured flexor tendons in a canine model. At 14-day follow-up, they found that ASC-sheet treatment modulated the post-repair inflammatory response and facilitated healing by increasing regenerative M2 macrophages, inflammatory inhibitor, and proteins involved in tendon formation. In addition, the combined administration of ASCs and rBMP-12 further stimulated M2 macrophages and led to the increase of M2 effector matrix metalloproteinase-12 involved in matrix remodeling, reduction of a negative regulator of angiogenesis and cell migration, and facilitated the proliferative stage of tendon repair. Learn more...

Comments (0)

There are no comments posted here yet

Submit Community Content

If you have orthopedic information that you would like to share with the Orthogate Community, please register/login and submit your news, event, job, article, case or workshop from the Submit Content menu under the My Account area. Learn more!