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The association between glomus tumors and neurofibromatosis.

J Hand Surg Am. 2013 Aug;38(8):1571-4

Authors: Harrison B, Moore AM, Calfee R, Sammer DM

Abstract
PURPOSE: To determine whether an epidemiologic association exists between glomus tumors and neurofibromatosis.
METHODS: Using a pathology database, we established a study cohort consisting of all patients who had undergone excision of a glomus tumor of the hand between 1995 and 2010. We created a control cohort by randomly selecting 200 patients who had undergone excision of a ganglion cyst over the same period. We reviewed medical records for each cohort to identify patients with a diagnosis of neurofibromatosis. We calculated the odds ratio was calculated and performed Fisher's exact test to determine the significance of the association.
RESULTS: We identified 21 patients with glomus tumors of the hand. Six of these patients carried the diagnosis of neurofibromatosis (29%). In contrast, no patients in the control group carried the diagnosis of neurofibromatosis. The odds ratio for a diagnosis of neurofibromatosis in association with a glomus tumor compared with controls was 168:1.


CONCLUSIONS: This study provides evidence of a strong epidemiologic association between glomus tumors and neurofibromatosis. Glomus tumor should be included in the differential diagnosis in neurofibromatosis patients who present with a painful lesion of the hand or finger.
TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic III.

PMID: 23849732 [PubMed - in process]

Read more... http://www.ncbi.nlm.nih.gov/pubmed/23849732?dopt=Abstract