The purpose of this study is to test whether the platelet-rich plasma (PRP)intra-articular injection therapy is effective as an alternative treatment option in patients with mild knee osteoarthritis within a controlled randomized study. The investigators will evaluate patients outcome in level of pain and quality of life at 3, 6 and 12 months follow up. The investigators will also analyze the biochemical environment in patient's joint before and after the treatment.

The study will be complemented with in vitro experiments of human osteoarthritic cartilage explants culture (and treated with PRP) for histological and gene expression assays.

PRP intra-articular injections therapy is effective in patients with mild knee osteoarthritis by modifying the biochemical joint environment and cartilage regeneration capability.

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