Inclusion Criteria:

  • Male or female, aged 45 to 80 years with a BMI ≤ 40
  • With an uni- or bilateral femorotibial knee osteoarthritis associated or not with a femoro-patellar knee osteoarthritis
  • Responding to clinical and radiological criteria of the ACR
  • Symptomatic for more than 6 months (for the most painful knee)
  • K&L radiological grade of Felson II or III
  • With a cartilage lesion identified during MRI and either at least 1 out of 4 MRI severity criteria:

    • bone oedema
    • meniscal lesion in the central region of the medial compartment
    • effusion without answer to corticosteroids
    • zone without cartilage
  • or at least 1 out of 3 clinical severity criteria:

    • genu varum>3°
    • previous meniscal surgery
    • known polyarthritis
    • effusion on the target knee
  • Sign an informed consent after being informed
  • Able to follow the instructions of the study
  • With an agreement from the physicians having established the diagnosis of osteoarthritis (if any) to give relevant information to the investigator
  • With health insurance (for France).

Exclusion Criteria:

For osteoarthritis:

  • Isolated patellofemoral arthritis
  • Chondromatosis or villo-nodular synovioma of the knee
  • Recent trauma-induced knee pain
  • Joint disease due to joint dysplasia, aseptic osteonecrosis, acromegaly, Paget's disease, hemophilia, hemochromatosis, …
  • inflammatory pathologies as rheumatoid polyarthritis, gout arthritis, infectious arthritis
  • Diseases that may interfere with the evaluation of osteoarthritis (radiculalgia of lower limbs, arteritis, …)
  • Genu valgum (degree considered as pathological by the physician)

For previous treatments:

• Treatment with strontium ranelate, bisphosphonates, SERM and PTH

For known associated diseases:

  • Serious associated diseases: severe liver or renal failure, uncontrolled cardiovascular disease, HIV, hepatitis B or C
  • Knee tumor

For patients:

  • Patient who participated to a therapeutic clinical trial 3 months before the T0 inclusion visit
  • Patient who are the subject of a judicial protection measure or under guardianship
  • Pregnant woman

For MRI contraindications:

  • Patient with a pacemaker, an implantable defibrillator, neurosurgical clips, a neurostimulator, cochlear implant, a stent, an insulin pump
  • Patient with a ferromagnetic splinter in the body, or having wire sutures
  • Serious mobility problem (Parkinson, tremors)

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